Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study.
Edward BurnSeng Chan YouAnthony G SenaKristin KostkaHamed AbedtashMaria Tereza Fernandes AbrahãoAmanda AlbergaHiba AlghoulOsaid H AlserThamir M AlshammariMaria AragonCarlos Morgado AreiaJuan M BandaJaehyeong ChoAedin C CulhaneAlexander DavydovFrank J DeFalcoTalita Duarte-SallesScott DuVallThomas FalconerSergio Fernandez-BertolinWeihua GaoAsieh GolozarJill HardinGeorge HripcsakVojtech HuserHokyun JeonYonghua JingChi Young JungBenjamin Skov Kaas-HansenDenys KadukSeamus KentYee Suk KimSpyros KolovosJennifer C E LaneHyejin LeeKristine E LynchRupa MakadiaMichael E MathenyParas P MehtaDaniel R MoralesKarthik NatarajanFredrik NybergAnna OstropoletsRae Woong ParkJimyung ParkJosé D PosadaAlbert Prats-UribeGowtham RaoChristian ReichYeunsook RhoPeter RijnbeekLisa M SchillingMartijn SchuemieNigam Haresh ShahAzza ShoaibiSeok-Young SongMatthew SpotnitzMarc A SuchardJoel N SwerdelDavid VizcayaSalvatore VolpeHaini WenAndrew E WilliamsBelay Birlie YimerLin ZhangOleg ZhukDaniel Prieto AlhambraPatrick RyanPublished in: Nature communications (2020)
Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.