GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation.
Simona Jurkovic MlakarSatyanarayana Chakradhara Rao UppugunduriTiago NavaVid MlakarHadrien GolayShannon RobinNicolas WaespeMohamed Aziz RezguiYves ChalandonJaap Jan BoelensRobert G M BrediusJean-Hugues DalleChristina PetersSelim CorbaciogluHenrique BittencourtMaja KrajinovicMarc Ansarinull nullPublished in: Journal of cancer research and clinical oncology (2021)
The clinical association suggests that GSTM1/GSTT1 double null genotype could serve as genetic stratification biomarker for the high risk of post-HSCT relapse. Functional studies have indicated that GSTM1 status modulates BU-induced cell death. On the other hand, GSTT1 is proposed to be involved in baseline cell proliferation.