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Generalized erythrodermic psoriasis triggered by vaccination against severe acute respiratory syndrome Coronavirus 2.

Tong Ba TranNhi Thi Uyen PhamHuy Ngoc PhanHao Trong Nguyen
Published in: Dermatologic therapy (2022)
Generalized erythrodermic psoriasis (GEP) is a rare and potentially life-threatening variant of psoriasis. Possible triggers that have been identified to date include poorly controlled psoriasis, medications, abrupt discontinuation of anti-psoriatic treatment, and underlying systemic illnesses. However, vaccines have rarely been reported to exacerbate GEP. Herein, we report two unique cases with GEP exacerbated following a dose of the BNT162b2 mRNA vaccine for COVID-19 (as their second dose, the first being the mRNA-1273 vaccine). Based on our observations and a literature review, vaccination was considered the most likely trigger of GEP due to the close temporal relationship between the second vaccination and the onset of GEP.
Keyphrases
  • respiratory syndrome coronavirus
  • sars cov
  • coronavirus disease
  • atopic dermatitis
  • rheumatoid arthritis
  • ankylosing spondylitis
  • disease activity
  • combination therapy