Women's Pregnancy Life History and Alzheimer's Risk: Can Immunoregulation Explain the Link?

Molly M FoxCarlo BerzuiniLeslie A KnappLaura M Glynn

Published in: American journal of Alzheimer's disease and other dementias (2018)

Our observation that first trimesters (but not third trimesters) conferred protection against AD is more consistent with immunologic effects, which are driven by early gestation, than estrogenic exposures, which are greatest in late gestation. Results may justify future studies with immune biomarkers.

Keyphrases

preterm infants
pregnancy outcomes
gestational age
preterm birth
polycystic ovary syndrome
air pollution
current status
cognitive decline
pregnant women
cervical cancer screening
breast cancer risk
estrogen receptor
mild cognitive impairment