A + T ± status across MCI and dementia due to AD: a clinic-based, retrospective study.
Federico VerdeEdoardo Nicolò AielloIlaria MiloneEleonora Giacopuzzi GrigoliAntonella DubiniAntonia RattiBarbara PolettiNicola TicozziVincenzo SilaniPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)
The distribution of A + T + vs. A + T- does not differ between MCI and ADD, with A + T + profiles being predominant in both clinical categories. This does not support the common notion of A + T- profiles being relatively more prevalent in MCI patients, as indexing an earlier and/or less severe disease. Hence, caution should be exerted in attributing a case of MCI to prodromal AD solely based on A-positivity in the presence of a T-negative profile.