Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles.
Mohammed Rabiul HosenPhilip Roger GoodyAndreas ZietzerXu XiangSven Thomas NiepmannAlexander SedaghatVedat TiyeriliRamesh ChennupatiJoseph B MooreReinier Abraham BoonShziuka UchidaJan-Malte SinningSebastian ZimmerEicke LatzNikos WernerGeorg NickenigFelix JansenPublished in: Circulation (2022)
Increased levels of circulating proapoptotic EV-incorporated miR-122-5p are associated with reduced LVEF after TAVR. EV shuttling of miR-122-5p regulates the viability and apoptosis of cardiomyocytes in a BCL2-dependent manner.
Keyphrases
- transcatheter aortic valve replacement
- aortic stenosis
- aortic valve
- left ventricular
- ejection fraction
- oxidative stress
- endoplasmic reticulum stress
- cell cycle arrest
- cell death
- mitral valve
- acute myocardial infarction
- high glucose
- coronary artery disease
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- acute coronary syndrome
- cell proliferation
- left atrial
- percutaneous coronary intervention