High FGF-21 level in a cohort of 22 patients with Dravet Syndrome-Possible relationship with the disease outcomes.
Anna Ka-Yee KwongVirginia Chun-Nei WongSheila Suet-Na WongVanessa Loi-Yan ChuSaskia KoeneJan SmeitinkCheuk-Wing FungPublished in: Epilepsia open (2021)
Significantly higher level of plasma FGF-21 was identified in DS patients. The high FGF-21 levels were shown to be associated with developmental outcome and valproate treatment. These results support further investigation on the relationship of FGF-21 with the clinical outcomes of DS and other related mechanism which is important for possible therapeutic development for this epileptic encephalopathy.