Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury.

Fawzi A BabikerIbrahim F BenterSaghir Akhtar

Published in: International journal of nanomedicine (2020)

Acute ex vivo or chronic in vivo treatment with naked G6 PAMAM dendrimer can significantly compromise recovery of non-diabetic hearts from I/R injury and can further negate the beneficial effects of PPC. Our findings are therefore extremely important in the nanotoxicological evaluation of G6 PAMAM dendrimers for potential clinical applications in physiological and pathological settings.

Keyphrases

ischemia reperfusion injury
liver failure
type diabetes
drug induced
oxidative stress
heart failure
atrial fibrillation
intensive care unit
risk assessment
climate change
acute respiratory distress syndrome