Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus.
Soo Heon KwakRyan B Hernandez-CancelaDaniel A DiCorpoDavid E CondonJordi MerinoPeitao WuJennifer A BrodyJie YaoXiuqing GuoAnke H Maitland-van der ZeeMariah MeyerMurat SincanJosep Maria MercaderSujin LeeJeffrey HaesslerHa My Thi VyZhaotong LinNicole D ArmstrongShaopeng GuNoah L TsaoLeslie A LangeNingyuan WangKerri L WigginsStella TrompetSimin LiuRuth J F LoosRenae JudyPhilip H SchroederNatalie R HasbaniMaxime M BosAlanna C MorrisonRebecca D JacksonAlexander P ReinerJo Ann E MansonNinad S ChaudharyLynn K CarmichaelYii-Der Ida ChenKent D TaylorMohsen GhanbariJoyce van MeursAchilleas N PitsillidesBruce M PsatyRaymond NoordamRon DoKyong Soo ParkJohan Wouter JukemaMaryam KavousiAdolfo CorreaStephen S RichScott M DamrauerCatherine HajekNam H ChoMarguerite R IrvinJames S PankowGirish Nitin NadkarniRobert SladekMark O GoodarziJose C FlorezDaniel I ChasmanSusan R HeckbertCharles KooperbergJosée DupuisRajeev MalhotraPaul S de VriesChing-Ti LiuJerome I RotterJames B MeigsPublished in: medRxiv : the preprint server for health sciences (2023)
There are genetic risk factors specific to T2D that could at least partially explain the excess risk of CVD in people with T2D.In addition, we show that people with T2D have enrichment of known CAD association signals which could also explain the excess risk of CVD.