Multiple Primary Melanoma: A Five-Year Prospective Single-Center Follow-Up Study of Two MC1R R/R Genotype Carriers.
Ana Maria Fagundes SortinoBianca Costa Soares de SáMarcos Alberto MartinsEduardo BertolliRafaela Brito de PaulaClovis Antônio Lopes PintoWaldec Jorge David FilhoJuliana Casagrande Tavoloni BragaJoão Pedreira Duprat NetoDirce Maria CarraroMaria Paula CuradoPublished in: Life (Basel, Switzerland) (2023)
This CM cohort is composed of 83.3% in-situ melanoma and 16.7% invasive melanoma. Both patients had a higher percentage of SPM with clinical nevus-like morphology (84.5%), global dermoscopic pattern of asymmetric multiple component (60.3%) and located on the lower limbs (46.6%). When RCM was performed prior to excision, 81% of SPM had features suggestive of malignancy. As well, invasive melanomas were more frequent in the lower limbs (40%). In the multivariate model, for the two high-risk patients studied, the chance of a not associated with nevus ("de novo") invasive SPM diagnosis is 25 times greater than the chance of a diagnosis of a nevus-associated invasive SPM.