VISTA expressed in tumour cells regulates T cell function.

Kumuluzi MulatiJunzo HamanishiNoriomi MatsumuraKenji ChamotoNathan MiseKaoru AbikoTsukasa BabaKen YamaguchiNaoki HorikawaRyusuke MurakamiMana TakiKharma BudimanXiang ZengYuko HosoeMiyuki AzumaIkuo KonishiMasaki Mandai

Published in: British journal of cancer (2018)

This is the first demonstration that VISTA is highly expressed in human ovarian and endometrial cancer cells, and that anti-VISTA antibody treatment significantly prolongs the survival of mice bearing tumours expressing high levels of VISTA. The data suggest that VISTA is a novel immunosuppressive factor within the tumour microenvironment, as well as a new target for cancer immunotherapy.

Keyphrases

induced apoptosis
endothelial cells
stem cells
cell cycle arrest
type diabetes
signaling pathway
adipose tissue
cell death
endoplasmic reticulum stress
endometrial cancer
deep learning
free survival
wild type