Association of Plasma Neurofilament Light with Postoperative Delirium.

Tamara G FongSarinnapha M VasunilashornLong NgoTowia A LibermannSimon T DillonEva M SchmittÁlvaro Pascual-LeoneSteven E ArnoldRichard N JonesEdward R MarcantonioSharon K Inouyenull null

Published in: Annals of neurology (2020)

Patients with the highest PREOP or POD2 NfL levels were more likely to develop delirium. Elevated NfL at PO1MO was associated with delirium and greater cognitive decline. These findings suggest NfL may be useful as a predictive biomarker for delirium risk and long-term cognitive decline, and once confirmed would provide pathophysiological evidence for neuroaxonal injury following delirium. ANN NEUROL 2020;88:984-994.

Keyphrases

cognitive decline
mild cognitive impairment
cardiac surgery
hip fracture
acute kidney injury
patients undergoing