Boosting Live Malaria Vaccine with Cytomegalovirus Vector Can Prolong Immunity through Innate and Adaptive Mechanisms.

parasitemia, and can be used to promote maintenance of antigen-specific CD4 T cells. In investigating the mechanisms of the MCMV booster, we found that the cytokine IFN-γ is required for prolonged protection and enhances priming of the innate immune system for prolonged protection from malaria. Our research informs both the quest for a longer-lived malaria vaccine and that to understand mechanisms of protection from persistent infection.