A lymphocyte-mediated cause of secondary PAP.

Published in: Blood (2015)

In this issue of Blood, Iriguchi et al report that T-lymphocyte–restricted overexpression of T-bet causes a maturational arrest in mononuclear phagocyte lineage cells and severe secondary pulmonary alveolar proteinosis (PAP).

Keyphrases

peripheral blood
induced apoptosis
cell cycle arrest
pulmonary hypertension
cell proliferation
cell cycle
transcription factor
endoplasmic reticulum stress
signaling pathway
pi k akt