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A lymphocyte-mediated cause of secondary PAP.
Bruce C Trapnell
Published in:
Blood (2015)
In this issue of Blood, Iriguchi et al report that T-lymphocyte–restricted overexpression of T-bet causes a maturational arrest in mononuclear phagocyte lineage cells and severe secondary pulmonary alveolar proteinosis (PAP).
Keyphrases
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peripheral blood
induced apoptosis
cell cycle arrest
pulmonary hypertension
cell proliferation
cell cycle
transcription factor
endoplasmic reticulum stress
signaling pathway
pi k akt