Micro-RNA content of circulating extracellular vesicles in early rheumatoid arthritis as biomarkers and mediators of methotrexate efficacy.

Daniel MaunderPhilip M BrownBen Barron-MillarDennis W LendremNajib NaamaneJamie MacdonaldXiao N WangJohn D IsaacsAmy E AndersonAnn W MorganRachel E CrosslandSarah L MackieArthur G Pratt

Published in: Rheumatology (Oxford, England) (2023)

Our data highlight the potential of serum EV miRs as diagnostic and therapeutic biomarkers, highlighting a novel potential mechanism via which MTX may exert its therapeutic effect in early RA that warrants further investigation.

Keyphrases

rheumatoid arthritis
disease activity
ankylosing spondylitis
electronic health record
interstitial lung disease
systemic lupus erythematosus
systemic sclerosis
idiopathic pulmonary fibrosis