Early-life origin and prevention of chronic obstructive pulmonary diseases.
Laura MoschinoSilvia CarraroEugenio BaraldiPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2020)
Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) have their roots in the womb. Together with a genetic predisposition, prenatal and early-life factors, including maternal smoking, prematurity, and bronchopulmonary dysplasia (BPD), have a pivotal role in later respiratory health. Then, inappropriate responses to respiratory viruses (especially respiratory syncytial virus and rhinovirus) and early allergic sensitization are the strongest contributors to the inception of wheezing and early-onset asthma. There is an urgent need for early disease biomarkers to identify profiles at higher risk of chronic respiratory conditions. Applying the "-omic" technologies to urine, blood and breath condensate, and non-invasive inflammometry seem promising in this regard. The description of specific risk profiles may be the key to the use of targeted personalized therapies.
Keyphrases
- early life
- chronic obstructive pulmonary disease
- early onset
- lung function
- respiratory syncytial virus
- late onset
- respiratory tract
- allergic rhinitis
- pregnant women
- preterm infants
- body mass index
- risk assessment
- dna methylation
- gene expression
- weight loss
- physical activity
- health promotion
- copy number
- breast cancer risk