Structural Basis for Designing Multiepitope Vaccines Against COVID-19 Infection: In Silico Vaccine Design and Validation.

Sukrit Srivastava Sonia Verma Mohit Kamthania Rupinder Kaur Ruchi Kiran Badyal Ajay Kumar Saxena Ho-Joon Shin Michael Kolbe Kailash C Pandey

Published in: JMIR bioinformatics and biotechnology (2020)

The present study is highly significant in terms of the molecular design of prospective CTL and HTL vaccines against SARS-CoV-2 infection with potential to elicit cellular and humoral immune responses. The epitopes of the designed MEVs are predicted to cover the large human population worldwide (96.10%). Hence, both designed MEVs could be tried in vivo as potential vaccine candidates against SARS-CoV-2.

Keyphrases

immune response
sars cov
structural basis
respiratory syndrome coronavirus
endothelial cells
human health
molecular docking
dendritic cells
induced pluripotent stem cells
single molecule
coronavirus disease
inflammatory response
molecular dynamics simulations