Cerebrospinal fluid levels of chromogranin A and phosphorylated neurofilament heavy chain are elevated in amyotrophic lateral sclerosis.

Michaela KaiserovaZ GrambalovaP OtrubaD StejskalH Prikrylova VranovaJ MaresK MensikovaP Kanovsky

Published in: Acta neurologica Scandinavica (2017)

Identifying CSF biomarkers in ALS is important in order to establish the diagnosis in the early stages of the disease. pNF-H seems to be a good biomarker for the diagnosis of ALS. If confirmed on a larger group of patients, CgA may also become useful in the diagnosis of sporadic ALS.

Keyphrases

cerebrospinal fluid
amyotrophic lateral sclerosis
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
late onset
patient reported outcomes