Electrospray Ionization Tandem Mass Spectrometric Study of Selected Phosphine-Based Ligands for Catalytically Active Organometallics.
Sarah FleissnerErnst PittenauerKarl KirchnerPublished in: Journal of the American Society for Mass Spectrometry (2023)
Selected organometallic compounds are nowadays extensively used as highly efficient catalysts in organic synthesis. A great variety of different ligand systems exists, of which phosphine-based ligands are a significant subgroup. While mass spectrometry, predominantly electrospray ionization mass spectrometry (ESI-MS), is a standard analytical technique for the identification of new ligands and their metal complexes, there is little information on the behavior of phosphine-based ligands/molecules by electrospray ionization collision-induced dissociation tandem mass spectrometry (ESI-CID-MS/MS) at low collision energies (<100 eV) in the literature. Here, we report a study on the identification of typical product ions occurring in tandem mass spectra of selected phosphine-based ligand systems by ESI-CID-MS/MS. The influence on the fragmentation behavior of different backbones (pyridine, benzene, triazine) as well as different spacer groups (amine, methylamine, methylene), which are directly linked to the phosphine moiety, is investigated by tandem mass spectrometry. In addition, possible fragmentation pathways are elaborated based on the assigned masses in the tandem mass spectra with high-resolution accurate mass determination. This knowledge may be particularly useful in the future for the elucidation of fragmentation pathways for coordination compounds by MS/MS, where the studied compounds serve as building blocks.
Keyphrases
- ms ms
- tandem mass spectrometry
- liquid chromatography
- mass spectrometry
- ultra high performance liquid chromatography
- solid phase extraction
- high performance liquid chromatography
- highly efficient
- high resolution
- gas chromatography
- high resolution mass spectrometry
- simultaneous determination
- liquid chromatography tandem mass spectrometry
- molecularly imprinted
- density functional theory
- systematic review
- capillary electrophoresis
- multidrug resistant
- diabetic rats
- clinical trial
- magnetic resonance imaging
- high glucose
- bioinformatics analysis
- drug induced
- multiple sclerosis
- oxidative stress
- quantum dots
- computed tomography
- current status
- high speed
- health information
- study protocol
- atomic force microscopy