Asymmetric Alkenylation of Enones and Imines Enabled by A Highly Efficient Aryl to Vinyl 1,4-Rhodium Migration.
Shu-Sheng ZhangTian-Jiao HuMeng-Yao LiYi-Kang SongXiao-Di YangChen-Guo FengGuo-Qiang LinPublished in: Angewandte Chemie (International ed. in English) (2019)
The asymmetric rhodium-catalyzed alkenylation of enones and imines with arylboronic acids has been developed. A highly controllable aryl to vinyl 1,4-rhodium migration is the key step. Stereodefined vinyl moieties were installed in excellent enantioselectivies for most examined examples. DFT calculations reveal that the driving force of this rhodium migration is a kinetically favored process.