Enabling migration by moderation: YAP/TAZ are essential for persistent migration.

Published in: The Journal of cell biology (2019)

Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.

Keyphrases

cell migration
single cell
cell therapy
stem cells
climate change
risk assessment
mesenchymal stem cells