Enabling migration by moderation: YAP/TAZ are essential for persistent migration.
Praful R NairDenis WirtzPublished in: The Journal of cell biology (2019)
Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.