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Enabling migration by moderation: YAP/TAZ are essential for persistent migration.

Praful R NairDenis Wirtz
Published in: The Journal of cell biology (2019)
Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.
Keyphrases
  • cell migration
  • single cell
  • cell therapy
  • stem cells
  • climate change
  • risk assessment
  • mesenchymal stem cells