Login / Signup

Clinical and Genotypic Insights Into Higher Prevalence of Palbociclib Associated Neutropenia in Asian Patients.

Jiun-I LaiTing-Hao KuoKuan-Jung HuangLaura Min Xuan ChaiMei-Hsuan LeeChun-Yu LiuYi-Fang TsaiChi-Cheng HuangLing-Ming TsengCheng-Chih HsuTa-Chung Chao
Published in: The oncologist (2023)
Our retrospective analysis of real world palbociclib use reveals an association with grade 3/4 neutropenia with better outcome and early neutropenia nadir with worse outcome. Our findings of Asian specific SNPs support a predisposition toward profound and prevalent neutropenia in Asian patients under CDK4/6i. We also report the first pharmacokinetics analysis on a patient with peritoneal dialysis receiving CDK4/6i. In summary, our study provides novel clinical and genotypic insights into CDK4/6i associated neutropenia.
Keyphrases