Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil.
Cleonice ZattiLuciano Santos Pinto GuimarãesMárcia Rosane Moreira SantanaEliana Ferreira Gonçalves SchernerEmílio SalleRenato PiltcherMariana Lunardi SpaderVitor Crestani CalegaroBianca Wollenhaupt-AguiarLúcia Helena Machado FreitasPublished in: Trends in psychiatry and psychotherapy (2019)
The population whose blood samples were collected in the afternoon showed significantly higher values of BDNF compared to those of the morning shift. This same population presented lower BDNF levels when associated with ASD subtypes A1, A2, and A. We hypothesize that the lower values of BDNF measured in the morning shift were due to a response to the circadian cycle of cortisol, whose action inhibits the expression of serum neurotrophins.