Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release.

Lin ZhouTong ZhangWei ShaoRuohan LuLin WangHaisheng LiuBin JiangShiqin LiHuiqin ZhuoSuheng WangQinxi LiCaihua HuangDong-Hai Lin

Published in: Skeletal muscle (2021)

Amiloride ameliorates cachectic muscle wasting and alleviates cancer cachexia progression through inhibiting tumor-derived exosome release. Our results are beneficial to understanding the underlying molecular mechanisms, shedding light on the potentials of amiloride in cachexia therapy.

Keyphrases

bone marrow
papillary thyroid
squamous cell
signaling pathway
mouse model
stem cells
young adults
childhood cancer
cell therapy