Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits.
Raquel DiezJuan José GarcíaMaría José DiezMatilde SierraAna M SahagunNélida FernándezPublished in: BMC complementary and alternative medicine (2017)
Plantago ovata husk increased the amount of absorbed metformin when included in the diet (significant increase in AUC), and delayed its absorption when administered at the same time (significant increase in tmax).