Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels.

Mark J Specterman Qadeer Aziz Yiwen LiNaomi A AndersonLeona OjakeKeat-Eng NgAlison M ThomasMalcolm C FinlayRichard J Schilling Pier D Lambiase Andrew Tinker

Published in: Circulation. Arrhythmia and electrophysiology (2023)

block/absence leads to cellular and tissue level atrial electrophysiological modification. Kir6.2 global knockout prevents hypoxia-induced atrial WFPL shortening and atrial arrhythmogenicity to programmed electrical stimulation. This mechanism could be explored translationally to treat ischemically driven atrial arrhythmia.

Keyphrases

atrial fibrillation
catheter ablation
left atrial
spinal cord injury
heart failure