The Combination of Salidroside and Hedysari Radix Polysaccharide Inhibits Mitochondrial Damage and Apoptosis via the PKC/ERK Pathway.

Sixia Yang Linshuang WangZeping XieYi ZengQiaowu XiongTingting PeiDongfeng Wei Weidong Cheng

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

-induced cytotoxicity through decreasing ROS levels, increasing MMP, inhibiting early apoptosis, and regulating PKC/ERK pathway in HT22 cells. CSH may be a potential therapeutic agent for treating or preventing neurodegenerative diseases.

Keyphrases

cell cycle arrest
pi k akt
signaling pathway
oxidative stress
cell death
induced apoptosis
diabetic rats
endoplasmic reticulum stress
cell proliferation
dna damage
high glucose
drug induced
endothelial cells
protein kinase