Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity.

Muhammad ShuaibSabir AdroubTobias MourierSara MfarrejHuoming ZhangLuke EsauAfrah AlsomaliFadwa S AlofiAdeel Nazir AhmadAbbas ShamsanAsim KhogeerAnwar M HashemNaif A M AlmontashiriSharif HalaArnab Pain

Published in: Genome medicine (2023)

Our data demonstrate an unforeseen connection between nucleocapsid KR mutations and augmented inflammatory immune response in severe COVID-19 patients. These findings provide insights into how mutations in SARS-CoV-2 modulate host immune output and pathogenesis and may contribute to more efficient therapeutics and vaccine development.

Keyphrases

sars cov
respiratory syndrome coronavirus
immune response
oxidative stress
coronavirus disease
dendritic cells
small molecule
early onset
big data
machine learning
artificial intelligence