Diagnosis and mitigation of the systemic impact of genome reduction in Escherichia coli DGF-298.
Antoine ChampieJean-Christophe LachanceAnand SastryDominick MatteauColton J LloydFrédéric GrenierCameron R LamoureuxSimon JeanneauAdam M FeistPierre-Étienne JacquesBernhard O PalssonSébastien RodriguePublished in: mBio (2024)
DGF-298 and identified a potential metabolic bottleneck leading to the constitutive activity of the SoxS iModulon. We then leveraged the model's predictions to successfully restore SoxS activity to the basal level.