Thrombotic microangiopathy associated with gemcitabine use: Presentation and outcome in a national French retrospective cohort.
Florence DavietFranck RoubyPascale PoullinJulie Moussi-FrancèsMarion SalléeStéphane BurteyJulien ManciniFlorence DuffaudRenaud SabatierBertrand PourroyAurélie GrandvuilleminSteven GrangeVéronique Frémeaux-BacchiPaul CoppoJoëlle MicallefNoémie Jourde-ChichePublished in: British journal of clinical pharmacology (2018)
This large cohort confirms the severity of G-TMA, associated with severe renal failure and death. Oedema and hypertension could be monitored in patients treated with gemcitabine to detect early TMA. The benefit of PE or eculizumab deserves further investigation.