Hyperactivation and altered selection of B cells in patients with paediatric Sjogren's syndrome.

Alessandra BoniRebecca NicolaiIvan CaielloFrancesca MarinaroLuciapia FarinaDenise Pires MarafonRita CarsettiFabrizio De BenedettiClaudia Bracaglia Emiliano Marasco

Published in: RMD open (2024)

Our results point to a hyperactivation of B cells in pSS. Current therapies do not seem to affect B cell abnormalities, suggesting that novel therapies targeting specifically B cell hyperactivation need to be implemented for paediatric patients.

Keyphrases

end stage renal disease
intensive care unit
emergency department
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
case report
cancer therapy
drug delivery