Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro.

Saja A AhmedAhmed F Al-ShanonAli Z Al-SaffarAlene TawangJameel R Al-Obaidi

Published in: Journal, genetic engineering & biotechnology (2023)

A significant increase in reactive oxygen species formation was observed. Caspase 8 and caspase 9 activities were estimated and AKBA activated the production of caspase 8 and caspase 9 in a dose-dependent pattern. Finally, the cell phase distribution analysis was conducted, and flow cytometric analysis showed that AKBA at 200 μg mL-1 significantly arrest MCF-7 cells at the G1 phase and triggered apoptosis.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
endoplasmic reticulum stress
pi k akt
oxidative stress
reactive oxygen species
signaling pathway
breast cancer cells
stem cells
single cell
cell therapy
data analysis