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Personalized Tuberculosis Treatment Through Model-Informed Dosing of Rifampicin.

Stijn W van BeekRob Ter HeineRon J KeizerCecile Magis-EscurraRob E AarnoutseElin M Svenson
Published in: Clinical pharmacokinetics (2020)
Blood sampling at 2 and 4 h, combined with model-based prediction, can be used instead of the currently used linear regression strategy, shortening the sampling by 2 h and one sampling point without performance loss while simultaneously offering flexibility in sampling times.
Keyphrases
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • emergency department
  • combination therapy
  • antiretroviral therapy