Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells.

Thanaporn KulthawatsiriYingpinyapat KittiratJutarop PhetcharaburaninJittima TomachaBundit PromraksaArporn WangwiwatsinPoramate KlanritAttapol TitapunWatcharin LoilomeNisana Namwat

Published in: PeerJ (2023)

Our findings unravel the mode of action of niclosamide in the energy depletion that could potentially serve as the promising therapeutic strategy for CCA treatment.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
risk assessment
cell proliferation