Near-Infrared Light-Triggered Chlorine Radical (. Cl) Stress for Cancer Therapy.
Ruixue SongHan WangMeng ZhangYanyan LiuXianfu MengShaojie ZhaiChao-Chao WangTeng GongYelin WuXingwu JiangWen-Bo BuPublished in: Angewandte Chemie (International ed. in English) (2020)
Free radicals with reactive chemical properties can fight tumors without causing drug resistance. Reactive oxygen species (ROS) has been widely used for cancer treatment, but regrettably, the common O2 and H2 O2 deficiency in tumors sets a severe barrier for sufficient ROS production, leading to unsatisfactory anticancer outcomes. Here, we construct a chlorine radical (. Cl) nano-generator with SiO2 -coated upconversion nanoparticles (UCNPs) on the inside and Ag0 /AgCl hetero-dots on the outside. Upon near-infrared (NIR) light irradiation, the short-wavelength emission UCNP catalyzes . Cl generation from Ag0 /AgCl with no dependence on O2 /H2 O2 . . Cl with strong oxidizing capacity and nucleophilicity can attack biomolecules in cancer cells more effectively than ROS. This . Cl stress treatment will no doubt broaden the family of oxidative stress-induced antitumor strategies by using non-oxygen free radicals, which is significant in the development of new anticancer agents.
Keyphrases
- reactive oxygen species
- cancer therapy
- cell death
- dna damage
- photodynamic therapy
- drinking water
- quantum dots
- drug delivery
- type diabetes
- highly efficient
- metabolic syndrome
- radiation therapy
- mass spectrometry
- adipose tissue
- skeletal muscle
- replacement therapy
- high resolution
- weight loss
- smoking cessation
- radiation induced