Aspirin and the Risk of Colorectal Cancer According to Genetic Susceptibility among Older Individuals.
Andrew BakshiYin CaoSuzanne G OrchardPrudence R CarrAmit D JoshiAlisa K ManningDaniel D BuchananAsad UmarIngrid M WinshipPeter GibbsZalcberg JohnFinlay MacraeJohn J McNeilPaul LacazeAndrew T ChanPublished in: Cancer prevention research (Philadelphia, Pa.) (2022)
There is strong evidence to support prophylactic aspirin use for the prevention of colorectal cancer. However recent recommendations suggest the risk of bleeding in older individuals outweighs the benefit. We sought to determine whether some older individuals might still benefit from aspirin based on their genetic susceptibility.