Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.

Yifeng ZhengNeng WangShengqi WangJuping ZhangBowen YangZhiyu Wang

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our findings shed new light on the association between chronic psychological stress and splenic MDSC mobilization, and suggest that stress-related glucocorticoid elevation can enhance TAM/CXCL1 signaling and subsequently recruit splenic MDSCs to promote PMN formation via CXCR2.

Keyphrases

squamous cell carcinoma
stress induced
small cell lung cancer
drug induced
sleep quality
young adults