Heterogeneity of Airway Smooth Muscle Remodelling in Asthma.

Alan L JamesGraham M DonovanFrancis H Y GreenThais MauadMichael J AbramsonAlvenia CairncrossPeter B NobleJohn G Elliot

Published in: American journal of respiratory and critical care medicine (2022)

ASM remodelling is related to asthma severity but is heterogenous within and between individuals and may contribute to the heterogenous functional defects observed in asthma. These findings support the need for patient-specific targeting of ASM remodelling.

Keyphrases

smooth muscle
chronic obstructive pulmonary disease
lung function
allergic rhinitis
cystic fibrosis