Comparison of Haploidentical Bone Marrow versus Matched Unrelated Donor Peripheral Blood Stem Cell Transplantation with Posttransplant Cyclophosphamide in Patients with Acute Leukemia.
Arnon NaglerMyriam LabopinBhagirathbhai R DholariaEmanuele AngelucciBoris AfanasyevJan J CornelissenSimona SicaEllen MeijerFabio CiceriGwendolyn Van GorkomNicolaus KrögerHans MartinPietro PioltelliAntonio RisitanoJonathan CanaaniBipin P SavaniJaime Sanz CaballerMohamad MohtyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
The use of a haplo donor with a BM graft resulted in a lower incidence of GvHD compared with a UD-PB stem cell graft in the setting of PTCy for patients with acute leukemia. However, differences in GvHD did not translate into a difference in survival outcomes. Based upon these data, UD-PB or haplo-BM should be considered equally acceptable sources for allo-HCT.