WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis.
Sungsin JoSubin WeonBora NamMi-Ae JangHyundeok KangTae-Jong KimYe-Soo ParkTae Hwan KimPublished in: Arthritis research & therapy (2021)
WNT16 is highly expressed in AS and WNT16 treatment facilitated cell senescence in AS-osteoprogenitor cells during osteoblast differentiation accompanied by suppression of bone formation. The identified role of WNT16 in AS could influence bone loss in AS patients.
Keyphrases
- ankylosing spondylitis
- cell proliferation
- stem cells
- bone loss
- single cell
- end stage renal disease
- cell therapy
- dna damage
- endothelial cells
- newly diagnosed
- induced apoptosis
- ejection fraction
- rheumatoid arthritis
- chronic kidney disease
- high glucose
- prognostic factors
- cell cycle arrest
- peritoneal dialysis
- diabetic rats
- mesenchymal stem cells
- cell death
- signaling pathway
- bone marrow
- drug induced
- endoplasmic reticulum stress
- pi k akt