Nevirapine inhibits migration and invasion in dedifferentiated thyroid cancer cells.

Hongxia ShangJunyu ZhaoJinming YaoHuanjun WangShengnan WangJianjun DongJianjun Dong

Published in: Thoracic cancer (2019)

Our findings suggest that nevirapine significantly repressed migration and invasion/metastasis in WRO 82-1 cells and tumor xenografts, which may be related to inhibition of IL-6/STAT3 signaling pathway. It promises great potential as a novel therapy for thyroid cancer, especially for those patients with metastasis.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
cell proliferation
oxidative stress
cell death
risk assessment
human health
drug induced