Genetic variants associated with syncope implicate neural and autonomic processes.
Hildur M AegisdottirRosa B ThorolfsdottirGardar SveinbjörnssonOlafur Andri StefanssonBjarni GunnarssonVinicius TraganteGudmar ThorleifssonLilja StefansdottirThorgeir E ThorgeirssonEgil FerkingstadPatrick SulemGudmundur NorddahlGudrun RutsdottirKarina BanasikAlex Hoerby ChristensenChristina MikkelsenOle Birger Vesterager PedersenSoren BrunakMie Topholm BruunChristian ErikstrupRikke Louise JacobsenKaspar René NielsenErik SørensenMichael L FriggeKristján Eldjárn HjörleifssonErna V IvarsdottirAnna HelgadottirSolveig GretarsdottirValgerdur SteinthorsdottirAsmundur OddssonHannes Petur EggertssonGisli Hreinn HalldorssonDavid A JonesJeffrey L AndersonKirk U KnowltonLincoln D Nadauldnull nullMagnus HaraldssonGudmundur ThorgeirssonHenning BundgaardDavid O ArnarUnnur ThorsteinsdottirDaníel F GuðbjartssonSisse Rye OstrowskiHilma HólmKári StefánssonPublished in: European heart journal (2023)
The results demonstrate that syncope has a distinct genetic architecture that implicates neural regulatory processes and a complex relationship with heart rate and blood pressure regulation. A shared genetic background with poor cardiovascular health was observed, supporting the importance of a thorough assessment of individuals presenting with syncope.