Emerging Role of LncRNAs in Ischemic Stroke-Novel Insights into the Regulation of Inflammation.
Yongli PanQingzheng JiaoWei WeiTianyang ZhengXinyu YangWenqiang XinPublished in: Journal of inflammation research (2021)
As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. Inflammation plays a vital role in the pathological process of ischemic stroke, and systemic inflammation affects the patient's prognosis. Although a great deal of research has illustrated that various lncRNAs are closely relevant to regulate neuroinflammation and microglial activation in ischemic stroke, the specific interactional relationships and mechanisms between lncRNAs and neuroinflammation have not been described clearly. This review aimed to summarize the therapeutic effects and action mechanisms of lncRNAs on ischemia by regulating inflammation and microglial activation. In addition, we emphasize that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NF-κB and ERK.
Keyphrases
- oxidative stress
- signaling pathway
- lps induced
- cell death
- genome wide identification
- lipopolysaccharide induced
- atrial fibrillation
- genome wide analysis
- network analysis
- pi k akt
- inflammatory response
- cerebral ischemia
- traumatic brain injury
- cell cycle arrest
- epithelial mesenchymal transition
- cognitive impairment
- endoplasmic reticulum stress
- neuropathic pain
- risk assessment
- white matter
- gene expression
- brain injury
- dna methylation
- immune response
- copy number
- subarachnoid hemorrhage
- vascular endothelial growth factor
- spinal cord injury
- climate change