Macrophage LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Is Required for the Effect of CD47 Blockade on Efferocytosis and Atherogenesis.

Paul A MuellerYoko KojimaKatherine T HuynhRichard A MaldonadoJianqin YeHagai TavoriNathalie Pamir Nicholas J Leeper Sergio Fazio

Published in: Arteriosclerosis, thrombosis, and vascular biology (2021)

The proefferocytosis receptor LRP1 in macrophages is necessary for anti-CD47 blockade to enhance efferocytosis, limit atherogenesis, and decrease necrotic core formation in the apoE-/- model of atherosclerosis.

Keyphrases

low density lipoprotein
cardiovascular disease
adipose tissue
cognitive decline
high fat diet
type diabetes
binding protein