Polymeric Nanocarriers with Luminescent Colloidal Nanoplatelets as Hydrophilic and Non-Toxic Two-Photon Bioimaging Agents.
Katarzyna Celina NawrotJan Kazimierz ZarebaMonika ToporkiewiczGrzegorz ChodaczekDominika WawrzynczykJulita KulbackaUrszula BazylinskaMarcin NykPublished in: International journal of nanomedicine (2021)
As a result, we obtained water dispersible and temporally stable hydrophilic NPLs-loaded NCs that offer excellent, both one- and two-photon excited fluorescence preserving optical properties of the raw hydrophobic and colloidal NPLs. The biological responses upon eukaryotic cells indicate that the encapsulation process protects cells from the toxic influence of cadmium simultaneously preserving the unique multiphoton properties of the active cargo which opens a promising perspective for its application in multiphoton cancer bioimaging excited at the "optical transmission window" of biological tissues in near-infrared range.
Keyphrases
- living cells
- energy transfer
- drug delivery
- quantum dots
- fluorescent probe
- cancer therapy
- single molecule
- liquid chromatography
- induced apoptosis
- drug release
- papillary thyroid
- cell cycle arrest
- sensitive detection
- high resolution
- gene expression
- squamous cell
- mass spectrometry
- heavy metals
- solid phase extraction
- monte carlo
- ionic liquid
- lymph node metastasis
- oxidative stress
- cell death
- cell proliferation
- electron transfer
- childhood cancer
- young adults