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Engineering the Redox-Driven Channel for Precisely Regulating Nanoconfined Glutathione Identification and Transport.

Tianpei GuanMing ChengLisi ZengXiaoya ChenYuan XieZiying LeiQiang RuanJin WangShuzhong CuiYao SunHaibing Li
Published in: ACS applied materials & interfaces (2021)
Bioinspired artificial nanochannels for molecular and ionic transport have extensive applications. However, it is still a huge challenge to achieve an intelligent transport system with high selectivity/efficiency and controllability. Inspired by glutathione transport across the plasma membrane via redox regulation, we herein designed and fabricated a redox-reactive artificial nanochannel based on the host-guest chemical strategy. The nanochannel platform achieved high selectivity/efficiency for the identification and transmission of glutathione in the confined space. In addition, this nanochannel can switch between the ON and OFF states through the redox reaction. This redox-regulated system can provide a potential application for detection/binding of biological analytes and redox-controlled drug release.
Keyphrases
  • drug release
  • electron transfer
  • transcription factor
  • risk assessment
  • ionic liquid
  • single molecule
  • single cell