Highly glycosylated CD147 promotes hemorrhagic transformation after rt-PA treatment in diabetes: a novel therapeutic target?

Yanan XieYingzhe WangHongyan DingMin GuoXun WangQiang DongMei Cui

Published in: Journal of neuroinflammation (2019)

CD147 is essential for diabetes-associated rt-PA-induced hemorrhagic transformation, and downregulation of CD147 glycosylation is a promising therapy for neurovascular-unit repair after rt-PA treatment of patients with diabetes.

Keyphrases

type diabetes
cardiovascular disease
cell proliferation
glycemic control
signaling pathway
metabolic syndrome
oxidative stress
adipose tissue
diabetic rats
weight loss