PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency.
Sheila K PiroozniaChangqing YuanMohammed Repon KhanSenthilkumar S KaruppagounderLuan WangYulan XiongSung Ung KangYunjong LeeValina L DawsonTed M DawsonPublished in: Molecular neurodegeneration (2020)
Our findings identify a highly conserved role for PINK1 and parkin in regulating mitochondrial biogenesis and promoting mitochondrial health via the PARIS/ PGC-1α axis. The Drosophila models described here effectively recapitulate the cardinal PD phenotypes and thus will facilitate identification of novel regulators of mitochondrial biogenesis for physiologically relevant therapeutic interventions.