Vactosertib, a Novel, Orally Bioavailable Activin Receptor-Like Kinase 5 Inhibitor, Promotes Regression of Fibrotic Plaques in a Rat Model of Peyronie's Disease.

Kang-Moon Song Doo Yong Chung Min-Ji Choi Kalyan Ghatak Nguyen Nhat Minh Anita Limanjaya Mi Hye Kwon Jiyeon Ock Guo Nan Yin Dae Kee Kim Ji Kan Ryu Jun Kyu Suh

Published in: The world journal of men's health (2019)

In view of the critical role of TGF-β and the Smad pathway in the pathogenesis of PD, inhibition of this pathway with an ALK5 inhibitor may represent a novel, targeted therapy for PD.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
advanced non small cell lung cancer
signaling pathway
tyrosine kinase