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Isocadiolides A-H: Polybrominated Aromatics from a Synoicum sp. Ascidian.

Jongkyoon BaeEunji ChoJae Sung ParkTae Hyung WonSu-Yuan SeoDong-Chan OhKi-Bong OhJongheon Shin
Published in: Journal of natural products (2020)
Isocadiolides A-H (1-8) and cadiolide N (9), new polybrominated aromatic compounds, were isolated from a Korean Synoicum sp. ascidian. On the basis of the results of extensive spectroscopic analyses, these compounds possessed tris-bromohydroxyphenyl moieties as a common structural motif, while their cores varied [cyclopentenedione (1-5), dihydrofuran (6 and 7), pyranone (8), and furanone (9)], reflecting different extents of rearrangement and oxidation. Several of these compounds exhibited weak antibacterial activities and moderate abilities to inhibit the microbial enzymes sortase A and isocitrate lyase.
Keyphrases
  • microbial community
  • molecular docking
  • high intensity
  • molecular dynamics simulations
  • wild type